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PrEP and ART could almost eliminate HIV infection

Combining PrEP and ART could almost eliminate HIV infection, east African study finds


First published on http://www.aidsmap.com/ on 26 Feb 2015


Gus Cairns
Jared Baeten presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

Jared Baeten presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

Giving both pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) to heterosexual couples where one partner has HIV (serodiscordant couples) can almost eliminate the chance of infection in the HIV-negative partner, a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA, yesterday has shown.

This study was a first in a number of ways. It is the first to combine the ideas of PrEP and of ‘treatment as prevention’ in a systematic and sequenced way. It is the first large study in Africa to use a ‘risk score’ specifically to target the intervention to those most at risk of HIV. And it is the first study of treatment as prevention to document near-elimination of HIV transmission not just from the HIV-positive partner in a serodiscordant couple, but also from extramarital partners. Read more

Early HIV treatment reduces risk of serious illness and death by 44%

Starting HIV treatment at CD4 count above 500 reduces the risk of serious illness and death by 44%, African Temprano trial shows


First published on http://www.aidsmap.com/ on 26 Feb 2015


Keith Alcorn

Christine Danel presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

Starting HIV treatment at a CD4 cell count above 500 reduced the risk of serious illness including tuberculosis (TB), and death, by 44% when compared to starting treatment according to World Health Organization (WHO) guidelines, results from the seven-year Temprano study show. The findings were presented on Wednesday at the Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA.

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