XDR-TB spread person-to-person, not by failure of drug

XDR-TB spread person-to-person, not by failure of drug treatment


First published on http://www.aidsmap.com/ on 26 Feb 2015


Keith Alcorn

N Sarita Shah presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

The vast majority of people with extensively drug-resistant tuberculosis (XDR-TB) diagnosed in the world’s most extensive outbreak have acquired their infection from another person, not as the result of the failure of treatment for multidrug-resistant strains of tuberculosis (MDR-TB), N Sarita Shah told the Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA, on Wednesday.

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PrEP and ART could almost eliminate HIV infection

Combining PrEP and ART could almost eliminate HIV infection, east African study finds


First published on http://www.aidsmap.com/ on 26 Feb 2015


Gus Cairns
Jared Baeten presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

Jared Baeten presenting at CROI 2015. Photo by Liz Highleyman, hivandhepatitis.com

Giving both pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) to heterosexual couples where one partner has HIV (serodiscordant couples) can almost eliminate the chance of infection in the HIV-negative partner, a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2015) in Seattle, USA, yesterday has shown.

This study was a first in a number of ways. It is the first to combine the ideas of PrEP and of ‘treatment as prevention’ in a systematic and sequenced way. It is the first large study in Africa to use a ‘risk score’ specifically to target the intervention to those most at risk of HIV. And it is the first study of treatment as prevention to document near-elimination of HIV transmission not just from the HIV-positive partner in a serodiscordant couple, but also from extramarital partners. Read more